Name | 2-[1-BENZYL-4-PIPERIDYL]-2-PHENYLGLUTARIMIDE |
Synonyms | R4929 dioxatrine mcn-jr4929 BENZETIMIDE HYDROCHLORIDE Benzetimide hydrochloride (R4929) 2-[1-BENZYL-4-PIPERIDYL]-2-PHENYLGLUTARIMIDE 2-(1-benzyl-4-piperidyl)-2-phenyl-glutarimidhydrochloride dl-2-(1-benzyl-4-piperidyl)-2-phenylglutarimidehydrochloride dl-1-benzyl-4-(2,6-dioxo-3-phenyl-3-piperidyl)piperidinehydrochloride 4'-bipiperidine)-2,6-dione,3-phenyl-1'-(phenylmethyl)-(monohydrochloride |
CAS | 5633-14-7 |
EINECS | 227-072-8 |
Molecular Formula | C23H27ClN2O2 |
Molar Mass | 398.93 |
Melting Point | 299-301.5℃ |
Solubility | H2O: 6.25mg/mL |
Appearance | powder |
Color | off-white |
Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
Stability | Hygroscopic |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
Safety Description | 36 - Wear suitable protective clothing. |
UN IDs | 3249 |
WGK Germany | 3 |
RTECS | MA4030000 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 in rats, mice (mg/kg): 37.6, 46.0 i.v. (Janssen) |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.507 ml | 12.534 ml | 25.067 ml |
5 mM | 0.501 ml | 2.507 ml | 5.013 ml |
10 mM | 0.251 ml | 1.253 ml | 2.507 ml |
5 mM | 0.05 ml | 0.251 ml | 0.501 ml |
biological activity | Benzetimide hydrochloride is an acetylcholine receptor antagonist with strong central and peripheral anticholinergic effects, can be used in the study of antipsychotic drugs caused by Parkinson's syndrome. |